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Research Use Only18+Not for Human ConsumptionReconstitution Materials Not Supplied
Peptide Database

Growth hormone & endocrine research

MGF (Mechano Growth Factor): Research Overview

Muscle-produced IGF-1 variant released after mechanical stress, studied in muscle repair research.

Also known as mechano growth factor · IGF-1Ec · Mechano Growth Factor

Research use onlyStrongest evidence: study type not statedReviewed
DatabaseReferences

What is MGF?

Non-pegylated IGF-1 splice variant produced locally in muscle tissue following mechanical stress. Has a very short half-life compared to PEG-MGF, requiring more frequent administration or localized injection.

What is MGF researched for?

  • Primary mechanism activating dormant muscle satellite cells which fuse to damaged fibers.
  • Naturally upregulated after mechanical stress; supplementation enhances repair processes.
  • Animal studies suggest improved tendon injury outcomes when applied locally.
  • Research indicates potential for bone healing via osteoblast regulation.

How does MGF work?

Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. The E-peptide domain exhibits distinct activity from mature IGF-1.

Pharmacokinetics

  • Short half-life means effects are concentrated at injection site.

References

  1. MGF-E Peptide Human Muscle Cell Study

    2011

    MGF significantly increased satellite cell proliferation at 3ng/ml with age-dependent effects.

  2. Mechano-Growth Factor Minireview

    2010

    Overview of MGF as IGF-I gene product involved in tissue repair, upregulated following exercise and injury.

Common questions

How is MGF different from PEG-MGF?

Standard MGF has a 5-7 minute half-life requiring daily injections. PEG-MGF (pegylated) lasts much longer (hours). Choose based on protocol preference: frequent localized doses (MGF) or fewer higher-dose injections (PEG-MGF). Effects are similar; administration differs.

Can MGF cause hypoglycemia?

Possibly, though less likely than IGF-1 LR3 due to MGF's very short half-life and localized action. However, the post-workout window and direct muscle injection make hypoglycemia unlikely. Still monitor early use and consume carbs post-injection as a precaution.