5-Amino-1MQ
NNMT Inhibitor · Longevity & Metabolic
Overview
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Improvement through mitochondrial efficiency.
Mechanism
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
Research areas
- Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
- Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
- Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
- NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
- Improvement through mitochondrial efficiency.
Research notes
- Generally minimal side effects
- Occasional mild GI adjustment
- Potential sleep interference if dosed late in day
- Severe gastrointestinal upset or persistent nausea
- Unusual fatigue or weakness (opposite of expected effect)
References
Questions
What is the difference between the mcg and mg protocols for 5-Amino-1MQ injection?
Two vastly different dosing protocols exist differing by 100-200x: the mcg protocol uses 150-500mcg daily while the mg protocol uses ~350mg (5mg/kg) daily. This massive discrepancy creates serious overdose risk. Always verify units (mcg vs mg) before reconstitution to avoid a potentially 100+ fold dosing error.
Does 5-Amino-1MQ actually increase NAD+ levels in humans?
Animal studies demonstrate significant NAD+ elevation through NNMT inhibition. A 2024 study showed aged mice treated with 5A1MQ gained ~40% greater grip strength vs controls, with improved intramuscular lipid content and muscle fiber cross-sectional area, providing evidence that NAD+ translates to functional…
Can I take 5-Amino-1MQ with food or does it need to be on an empty stomach?
Take 5-Amino-1MQ with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels, and morning or early afternoon dosing is preferred to avoid potential sleep interference.