5-Amino-1MQ
NNMT Inhibitor · Longevity & Metabolic Enhancement
Overview
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Improvement through enhanced mitochondrial efficiency.
Mechanism
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Research areas
- 5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
- Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
- Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
- Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
- Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
- Improvement through enhanced mitochondrial efficiency.
- Enhancement via cellular energy optimization.
- Improved glucose/fat substrate switching.
- Supports increased basal metabolic rate.
- Improvements in fat burning capacity.
Research notes
- Generally minimal side effects
- Occasional mild GI adjustment
- Potential sleep interference if dosed late in day
- Severe gastrointestinal upset or persistent nausea
- Unusual fatigue or weakness (opposite of expected effect)
- Persistent headaches or dizziness
- Sleep disturbances or insomnia
- Allergic reactions (rash, swelling, difficulty breathing)
- Significant mood changes or anxiety
- Pregnancy or breastfeeding
- Pre-existing metabolic conditions (consult healthcare provider)
- Week 1-2 shows gradual energy increase and mental clarity. Week 2-4 brings enhanced exercise performance and recovery. Week 4-8 shows improved metabolic markers and body composition changes. Peak longevity benefits with sustained cellular health improvements appear by week 8-12 with continuous use.
References
FAQs
What is the difference between the mcg and mg protocols for 5-Amino-1MQ injection?
Two vastly different dosing protocols exist differing by 100-200x: the mcg protocol uses 150-500mcg daily while the mg protocol uses ~350mg (5mg/kg) daily. This massive discrepancy creates serious overdose risk. Always verify units (mcg vs mg) before reconstitution to avoid a potentially 100+ fold dosing error.
Does 5-Amino-1MQ actually increase NAD+ levels in humans?
Animal studies demonstrate significant NAD+ elevation through NNMT inhibition. A 2024 study showed aged mice treated with 5A1MQ gained ~40% greater grip strength vs controls, with improved intramuscular lipid content and muscle fiber cross-sectional area, providing evidence that NAD+ enhancement translates to functional improvements.
Can I take 5-Amino-1MQ with food or does it need to be on an empty stomach?
Take 5-Amino-1MQ with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels, and morning or early afternoon dosing is preferred to avoid potential sleep interference.