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Research Use Only18+Not for Human ConsumptionReconstitution Materials Not Supplied
Peptide Database

Longevity & cellular research

5-Amino-1MQ: Research Overview

Small molecule studied for its effect on NAD+ levels and fat metabolism. Not a peptide.

Also known as 5A1MQ

Research use onlyStrongest evidence: animal studyReviewed
DatabaseReferences

What is 5-Amino-1MQ?

Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.

What is 5-Amino-1MQ researched for?

  • Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
  • Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
  • Improvement through enhanced mitochondrial efficiency.
  • Enhancement via cellular energy optimization.
  • Improved glucose/fat substrate switching.
  • Supports increased basal metabolic rate.
  • Improvements in fat burning capacity.

How does 5-Amino-1MQ work?

Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.

References

  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

    Neelakantan H, Vance V, Wetzel MD, et al. · Biochemical pharmacology · 2018

    Diet-induced obese mice showed significant weight loss and adipocyte size reduction with 5-amino-1MQ treatment. Demonstrated that NNMT inhibition increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance.

    Animal study · PMID 29155147

  2. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

    Awosemo O, Neelakantan H, Watowich S, et al. · Journal of pharmaceutical and biomedical analysis · 2021

    Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Validated sensitive LC-MS/MS method for pharmacokinetic assessment supporting oral administration viability.

    Animal study · PMID 34304009

  3. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice

    Dimet-Wiley AL, Latham CM, Brightwell CR, et al. · Scientific reports · 2024

    NNMTi-treated aged sedentary mice showed ~40% greater grip strength than controls. Combined with exercise, 60% grip strength increase. Also improved intramuscular lipid content and gastrocnemius fiber cross-sectional area.

    Animal study · PMID 38969654

Common questions

Does 5-Amino-1MQ actually increase NAD+ levels in humans?

Animal studies demonstrate significant NAD+ elevation through NNMT inhibition. A 2024 study showed aged mice treated with 5A1MQ gained ~40% greater grip strength vs controls, with improved intramuscular lipid content and muscle fiber cross-sectional area, providing evidence that NAD+ enhancement translates to functional improvements.