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Research Use Only18+Not for Human ConsumptionReconstitution Materials Not Supplied
Peptide Database

Longevity & cellular research

Chonluten (EDG): Research Overview

Khavinson bioregulator tripeptide studied in respiratory tissue research.

Also known as EDG · Glu-Asp-Gly

Research use onlyStrongest evidence: review or meta-analysisReviewed
DatabaseReferences

What is Chonluten?

Chonluten is a Khavinson bioregulator tripeptide (EDG) derived from respiratory lung tissue. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it targets the bronchopulmonary system with secondary activity in the GI tract. Research shows it regulates genes related to inflammation, antioxidant activity, and proliferation responses.

What is Chonluten researched for?

  • Normalizes respiratory system function through gene expression regulation.
  • Restores and maintains lung alveolar tissues and bronchial mucous membranes.
  • May modulate mucosal function in chronic obstructive pulmonary disease.
  • Inhibits TNF production in monocytes, reducing inflammatory responses.
  • Supports SOD and antioxidant gene expression.
  • Researched as potential agent that may slow cell aging.
  • Modulates c-Fos and proliferative gene activity.

How does Chonluten work?

Chonluten works through epigenetic regulation, penetrating cell and nuclear membranes to bind promoter or suppressor regions of DNA and modulate transcriptional control. It regulates genes including c-Fos, HSP70 (heat-shock protein), SOD (superoxide dismutase), COX-2, and TNF-alpha related to oxidative stress and proliferative regulation.

References

  1. Peptides Regulating Proliferative Activity and Inflammatory Pathways in THP-1 Cells PMC/NCBI

    2022

    Chonluten tripeptide inhibits TNF production in monocytes exposed to pro-inflammatory LPS.

  2. Chonluten and Gene Expression Regulation

    Advances in Gerontology · 2018

    Chonluten regulates c-Fos, HSP70, SOD, COX-2, and TNF-alpha gene expression.

  3. Bronchial Bioregulator Peptides

    Bulletin of Experimental Biology and Medicine · 2016

    Short peptides derived from bronchial tissue regulate protein synthesis in lung cells.

  4. Khavinson Peptide Bioregulators

    Advances in Gerontology · 2020

    Comprehensive review of bioregulator peptides including Chonluten and their mechanisms.

    Review or meta-analysis

Common questions

What makes Chonluten different from other immune-supporting peptides?

Chonluten is specifically derived from bronchial lung tissue and targets the respiratory system primarily, unlike broad immune peptides. It regulates genes like c-Fos, HSP70, SOD, and TNF-alpha to reduce inflammatory responses and support lung tissue health, making it unique for respiratory-specific immune modulation.