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Research Use Only18+Not for Human ConsumptionReconstitution Materials Not Supplied
Peptide Database

Metabolic & GLP-1 research

Pancragen (KEDW): Research Overview

Khavinson bioregulator peptide studied in pancreatic tissue and glucose research.

Also known as KEDW · Lys-Glu-Asp-Trp

Research use onlyStrongest evidence: animal studyReviewed
DatabaseReferences

What is Pancragen?

Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression.

What is Pancragen researched for?

  • Corrects age-related glucose tolerance disturbances in primate studies.
  • Reduces incidence and magnitude of metabolic syndrome.
  • Helps control blood sugar through pancreatic function support.
  • Impacts differentiation of pancreatic cells during aging.
  • Improves endocrine function of the pancreas.
  • Addresses age-related imbalance of pancreatic function.
  • Directly interacts with DNA to regulate pancreatic gene expression.

How does Pancragen work?

Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures to modulate pancreatic gene expression. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4.

References

  1. Correction of Impaired Glucose Tolerance Using Tetrapeptide (Pancragen) in Old Female Rhesus Monkeys PubMed

    2017

    Pancragen normalized insulin and C-peptide levels, suggesting recovery of disturbed glucose tolerance in old animals.

    Animal study

  2. Tetrapeptide KEDW Interacts with DNA and Regulates Gene Expression

    Bulletin of Experimental Biology and Medicine · 2015

    KEDW directly interacts with DNA and regulates pancreatic gene expression.

  3. Impacts of Pancragen on Differentiation of Pancreatic Cells During Aging

    Bulletin of Experimental Biology and Medicine · 2013

    Pancragen affects pancreatic cell differentiation during aging process.

  4. Prospects of Using Pancragen for Metabolic Disorders in Elderly

    Bulletin of Experimental Biology and Medicine · 2011

    Pancragen shows promise for correction of metabolic disorders in elderly people.

Common questions

Does Pancragen actually cure glucose intolerance, or just mask it?

Pancragen works through epigenetic regulation—it directly interacts with DNA to upregulate pancreatic transcription factors. In primate studies, it normalized insulin and C-peptide levels, suggesting actual restoration of pancreatic function rather than masking. However, this only works for age-related glucose tolerance decline, not for Type 1 diabetes or severe pancreatic damage.