Reproductive & sexual-function research
Prostamax (KEDP): Research Overview
Khavinson bioregulator peptide studied in prostate tissue research.
Also known as KEDP · Lys-Glu-Asp-Pro
What is Prostamax?
Prostamax is a Khavinson bioregulator tetrapeptide (KEDP) with primary repair effects on prostate tissue. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it alters chromatin structure in cells from elderly individuals, promoting deheterochromatinization and potentially reactivating genes repressed during aging.
What is Prostamax researched for?
- Research shows reduced inflammation and swelling in prostatitis models.
- Mitigates inflammation and immune cell infiltration in prostate tissue.
- Decreases scarring and pathological remodeling in prostate.
- Promotes deheterochromatinization in elderly cells.
- Potentially reactivates genes repressed during aging process.
- Normalizes age-related changes in lymphocyte function.
How does Prostamax work?
Prostamax works through epigenetic regulation by altering chromatin structure. It increases the frequency of sister chromatid exchanges and Ag-positive nucleolar organizer regions (NORs), while reducing large segments of pericentromeric heterochromatin. These changes promote chromatin decondensation and deheterochromatinization, potentially reactivating genes repressed during aging.
References
Experimental Studying of Drug Efficiency Prostamax in Therapy of Chronic Aseptic Prostatitis
Bulletin of Experimental Biology and Medicine · 2013
Prostamax reduced prostate swelling, inflammation, and scarring in rat prostatitis models.
Animal study
Effects of Short Peptides on Lymphocyte Chromatin in Senile Subjects
Bulletin of Experimental Biology and Medicine · 2004
KEDP peptide alters chromatin structure, promoting deheterochromatinization in elderly cells.
Deheterochromatinization of Chromatin in Old Age Induced by Oligopeptide Bioregulator (Lys-Glu-Asp-Pro) Georgian Medical News
2012
Prostamax promotes chromatin decondensation and reactivates age-repressed genes.
Khavinson Peptide Bioregulators
Advances in Gerontology · 2020
Comprehensive review of bioregulator peptides and their epigenetic mechanisms.
Review or meta-analysis
Common questions
How does Prostamax reduce prostate swelling without hormone manipulation?
Prostamax works through epigenetic chromatin remodeling—it alters the physical structure of chromatin by increasing sister chromatid exchanges and decreasing heterochromatin. This promotes 'deheterochromatinization,' reactivating genes silenced during aging. It doesn't block hormones; it resets gene expression patterns in prostate cells.