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Peptide Database

Skin & dermatology research

SNAP-8 (Acetyl Octapeptide-3): Research Overview

Topical cosmetic peptide studied for its effect on expression lines.

Also known as Acetyl Octapeptide-3 · acetyl glutamyl heptapeptide-1

Research use onlyStrongest evidence: controlled clinical trialReviewed
DatabaseReferences

What is SNAP-8?

Synthetic octapeptide functioning as topical Botox alternative, targeting dynamic facial wrinkles through SNARE complex modulation. Up to 63% wrinkle depth reduction demonstrated clinically.

What is SNAP-8 researched for?

  • Demonstrates up to 63% reduction in wrinkle depth around eyes/forehead over 28 days.
  • Targets horizontal lines from repetitive eyebrow-raising and facial expressions.
  • Reduces periorbital wrinkles via localized muscle relaxation without affecting natural expressions.
  • 43% inhibition efficiency at therapeutic concentrations.
  • Localized relaxation at application sites without systemic effects.
  • Slows new expression line formation before becoming static wrinkles.

How does SNAP-8 work?

Mimics SNAP-25 protein N-terminal, competitively inhibits SNARE complex formation, reduces acetylcholine release at neuromuscular junctions.

References

  1. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study

    Wang Y, Wang M, Xiao S, et al. · American journal of clinical dermatology · 2013

    60 subjects randomized 3:1 argireline vs placebo. Total anti-wrinkle efficacy 48.9% argireline vs 0% placebo (P<0.01). Roughness parameters significantly decreased. First multicenter RCT of the parent compound.

    Controlled clinical trial · PMID 23417317

  2. A synthetic hexapeptide (Argireline) with antiwrinkle activity

    Blanes-Mira C, Clemente J, Jodas G, et al. · International journal of cosmetic science · 2002

    10% argireline emulsion reduced wrinkle depth up to 30% in 30 days. Mechanism: competitive inhibition of SNARE complex formation with potency similar to BoNT-A but non-toxic.

    PMID 18498523

  3. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy

    Errante F, Ledwoń P, Latajka R, et al. · Frontiers in chemistry · 2020

    SNAP-8 demonstrated 43% SNARE complex inhibition at therapeutic concentrations. Synergistic with Leuphasyl: 47% total inhibition combined vs 38% and 7% independently.

    PMID 33195061

  4. Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects Kim JH, et al. Annals of Dermatology

    2024

    24 subjects evaluated dissolving microneedle patch with acetyl octapeptide-3 (SNAP-8). Enhanced wrinkle reduction vs topical alone, improved skin elasticity and lifting with no adverse effects over 28 days.

  5. Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities

    Shin JY, Han D, Yoon KY, et al. · Annals of dermatology · 2024

    PMID 39082657

Common questions

How does SNAP-8 compare to Botox in terms of wrinkle reduction?

SNAP-8 achieves up to 63% wrinkle depth reduction topically, while Botox is ~95%+ for injection. Botox works faster (3-7 days) and lasts longer (3-4 months). SNAP-8 takes 4-6 weeks and effects fade in 2-4 weeks post-discontinuation. SNAP-8 is a non-invasive alternative with results closer to strong topicals than true Botox equivalence.