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Peptide Database

Cognition & neuromodulation

Selank

Anxiolytic & Nootropic Peptide · Tuftsin Analog

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Overview

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.

Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.

Clinical trials show significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation or amnesia.

Research indicates effectiveness in PTSD treatment.

Reduces anticipatory anxiety and performance stress.

Mechanism

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.

Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.

Clinical trials show significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation or amnesia.

Research areas

  • Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.
  • Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.
  • Clinical trials show significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation or amnesia.
  • Research indicates effectiveness in PTSD treatment.
  • Reduces anticipatory anxiety and performance stress.

Research notes

  • Minimal side effects - excellent safety profile
  • No sedation or cognitive impairment
  • No tolerance, dependence, or withdrawal
  • Severe allergic reactions (rash, breathing difficulty, swelling)
  • Persistent injection site reactions or infection signs

References

Questions

Will Selank help with PTSD, or is it just for generalized anxiety?

Selank is documented to help PTSD. Research shows effectiveness in PTSD treatment (rated as 'effective'). It modulates stress response through multiple systems (GABA, serotonin, dopamine, BDNF), which addresses trauma-related dysregulation. However, it's typically used alongside proper PTSD therapy, not as sole…

How does Selank's 30% BDNF increase compare to other nootropics?

It's significant. A 30% increase in hippocampal BDNF supports neuroplasticity and long-term potentiation (learning/memory). Semax shows similar effects. Compounds like noopept also increase BDNF, but through different pathways. Selank's unique value is anxiety relief plus BDNF elevation without sedation—a rare…