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Peptide Database

Cognitive & neurological research

NA-Selank Amidate (N-Acetyl Selank Amidate): Research Overview

Chemically stabilised Selank variant studied in anxiety and cognition research.

Also known as N-Acetyl Selank Amidate

Research use onlyStrongest evidence: study type not statedReviewed
DatabaseReferences

What is NA-Selank Amidate?

NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding.

What is NA-Selank Amidate researched for?

  • Standard Selank approved in Russia for GAD; NA-Selank Amidate offers enhanced delivery.
  • Modulates stress response through GABA and serotonin systems without sedation.
  • Improves mood through serotonin metabolism activation.
  • Increases memory trace stability for up to 30 days in animal studies.
  • BDNF elevation supports learning and neuroplasticity.
  • BDNF increase reduces effects of neurological injury.
  • Based on tuftsin structure, retains immunomodulatory properties.

How does NA-Selank Amidate work?

NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines.

References

  1. Selank Administration Affects Expression of Genes in GABAergic Neurotransmission Frontiers in

    Pharmacology · 2016

    Selank modulates GABAA receptor activity, contributing to anxiolytic effects without benzodiazepine-like side effects.

  2. Selank Clinical Trial in Anxiety Disorders Zhurnal Nevrologii i Psikhiatrii

    2008

    14 days of intranasal Selank produced pronounced anxiolytic and mild nootropic effects; benefits persisted 1 week post-treatment.

  3. Selank and Serotonin Metabolism

    Bulletin of Experimental Biology and Medicine · 2006

    Single Selank injection activated serotonin metabolism and increased memory trace stability for up to 30 days.

  4. Selank and BDNF Expression Regulatory Peptides

    2009

    Selank administration increases BDNF levels, supporting neuronal growth and memory enhancement.

Common questions

How is NA-Selank Amidate different from standard Selank?

NA-Selank Amidate has two key modifications: N-terminal acetylation and C-terminal amidation. These changes enhance blood-brain barrier penetration, create more stable metabolites, and extend the half-life compared to standard Selank. The result is superior anxiolytic and cognitive effects with potentially longer duration of action.