TB-500 (Thymosin Beta-4 Fragment)

Synthetic Fragment (17-23) of Thymosin Beta-4

Overview

A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation.

Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.

Accelerated healing of muscle fibers with reduced recovery time and enhanced repair via cell migration and differentiation.

Connective tissue repair with reduced scar formation and improved biomechanical properties of healing tissues.

Enhanced dermal closure, improved angiogenesis, and reduced inflammation in acute and chronic scenarios.

Faster recovery from intense training with reduced muscle soreness and improved tissue repair.

Mechanism

Accelerated healing of muscle fibers with reduced recovery time and enhanced repair via cell migration and differentiation.

Research areas

A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation.
Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.
Accelerated healing of muscle fibers with reduced recovery time and enhanced repair via cell migration and differentiation.
Connective tissue repair with reduced scar formation and improved biomechanical properties of healing tissues.
Enhanced dermal closure, improved angiogenesis, and reduced inflammation in acute and chronic scenarios.
Faster recovery from intense training with reduced muscle soreness and improved tissue repair.
Strengthened tissues through enhanced repair mechanisms may reduce injury risk.
Improved muscle quality through enhanced regeneration and repair pathways.
Protective effects against neuronal damage in various models.
Preclinical evidence for improved outcomes in spinal injury models.
Potential neuroprotective and regenerative effects on brain tissue.

Research notes

Generally minimal side effects
Possible mild injection site reactions
Temporary fatigue in some users
Persistent or worsening injection site infections
Unusual swelling or prolonged redness
Severe allergic reactions
Unexpected systemic symptoms
Concerning health changes
Active cancer treatment (due to angiogenic effects)
Pregnancy or breastfeeding
Immunosuppressive medications (consult provider)
WADA prohibited for competitive athletes
TB-500's healing benefits persist for weeks to months after completing a 6-8 week cycle due to sustained improvements in tissue quality, angiogenesis, and stem cell mobilization. However, maintenance doses every 1-2 weeks may be needed for chronic conditions requiring ongoing support.

AXIOM catalogue

TB-500 — research-use catalogue record with strengths and available batch details where listed.

References

FAQs

Can TB-500 be injected directly at the injury site or must it be systemic?

TB-500 can be injected directly near injury sites or systemically. Local injection near tendon/ligament injuries may accelerate healing by concentrating effects, but systemic SubQ or IM administration provides comprehensive tissue repair through systemic circulation and is more commonly used.

Is TB-500 banned in sports and why?

Yes, TB-500 is prohibited by WADA in competitive sports because it enhances cellular regeneration and muscle repair, providing unfair athletic advantage. Athletes should avoid use if subject to anti-doping testing.

What's the difference between TB-500 and the TB-500 fragment (Ac-LKKTETQ)?

Full TB-500 is the complete 43-amino-acid thymosin beta-4, while the fragment is just the bioactive 7-amino-acid core (LKKTETQ). Both work similarly, but the fragment is smaller, more stable, and potentially more economical while retaining core wound-healing and regenerative properties.