TB-500 (Thymosin Beta-4 Fragment)
Synthetic Fragment (17-23) of Thymosin Beta-4
Overview
A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem…
Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.
Accelerated healing of muscle fibers with reduced recovery time and repair via cell migration and differentiation.
Connective tissue repair with reduced scar formation and improved biomechanical properties of healing tissues.
dermal closure, improved angiogenesis, and reduced inflammation in acute and chronic scenarios.
Mechanism
A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem…
Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.
Accelerated healing of muscle fibers with reduced recovery time and repair via cell migration and differentiation.
Research areas
- A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem…
- Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.
- Accelerated healing of muscle fibers with reduced recovery time and repair via cell migration and differentiation.
- Connective tissue repair with reduced scar formation and improved biomechanical properties of healing tissues.
- dermal closure, improved angiogenesis, and reduced inflammation in acute and chronic scenarios.
Research notes
- Generally minimal side effects
- Possible mild injection site reactions
- Temporary fatigue in some users
- Persistent or worsening injection site infections
- Unusual swelling or prolonged redness
References
- pubmed.ncbi.nlm.nih.gov/23050815/
- pubmed.ncbi.nlm.nih.gov/17947592/
- pubmed.ncbi.nlm.nih.gov/34346165/
- pubmed.ncbi.nlm.nih.gov/25826322/
- pubmed.ncbi.nlm.nih.gov/36613994/
- pubmed.ncbi.nlm.nih.gov/20126456/
Questions
Can TB-500 be injected directly at the injury site or must it be systemic?
TB-500 can be injected directly near injury sites or systemically. Local injection near tendon/ligament injuries may accelerate healing by concentrating effects, but systemic SubQ or IM administration provides comprehensive tissue repair through systemic circulation and is more commonly used.
Is TB-500 banned in sports and why?
Yes, TB-500 is prohibited by WADA in competitive sports because it cellular regeneration and muscle repair, providing unfair athletic advantage. Athletes should avoid use if subject to anti-doping testing.
What's the difference between TB-500 and the TB-500 fragment (Ac-LKKTETQ)?
Full TB-500 is the complete 43-amino-acid thymosin beta-4, while the fragment is just the bioactive 7-amino-acid core (LKKTETQ). Both work similarly, but the fragment is smaller, more stable, and potentially more economical while retaining core wound-healing and regenerative properties.