Tissue repair & recovery research
Cartalax (AED peptide): Research Overview
Khavinson bioregulator tripeptide studied in cartilage and connective tissue research.
Also known as AED · Ala-Glu-Asp · AED peptide
What is Cartalax?
Synthetic tripeptide developed by Professor Vladimir Khavinson, supporting cartilage, connective tissue, and cellular regeneration through proliferation markers and apoptosis pathway modulation.
What is Cartalax researched for?
- Clinical efficacy shown in osteochondrosis, osteoarthritis, and osteoporosis treatment.
- Supports cartilage maintenance and joint function.
- Supports bone and connective tissue healing.
- Increased Ki-67 expression with suppressed apoptosis in young and aged cells.
- Enhances collagen synthesis in connective tissue.
- Inhibited MMP-9 synthesis; maintained extracellular matrix integrity.
How does Cartalax work?
Modulates cell proliferation, suppresses apoptosis, affects fibroblast activity, reduces senescence markers, and influences extracellular matrix preservation.
References
Fibroblast Proliferation Study
2019
Human skin fibroblasts; 72 hours at 20 nM. Increased Ki-67 expression with suppressed apoptosis in young and aged cells.
Laboratory study
Kidney Cell Culture Research
2020
Renal epithelial cells; 7 days. Reduced pro-apoptotic p53 expression in aging kidney cells.
Laboratory study
Clinical Spine & Joint Study
Human subjects; 1-3 months with 0.1mg capsules daily. Efficacy in osteochondrosis, osteoarthritis, and osteoporosis treatment.
Early human study
Matrix Metalloproteinase Research
2020
Fibroblast cultures; 5 days at 20 nM. Inhibited MMP-9 synthesis; maintained extracellular matrix integrity.
Laboratory study
Common questions
How does Cartalax help cartilage if cartilage doesn't have blood vessels to deliver it?
Cartalax works through systemic effects on fibroblasts and gene expression. Once in circulation, it reaches fibroblasts throughout connective tissue, stimulating collagen production and suppressing matrix-degrading enzymes like MMP-9. This systemic fibroblast activation supports cartilage maintenance and collagen preservation even in avascular cartilage.
Can Cartalax reverse osteoarthritis or just prevent progression?
Russian clinical studies show efficacy in established osteoarthritis, osteochondrosis, and osteoporosis treatment. However, 'reverse' is overstated—Cartalax supports tissue repair and slows degeneration better than it rebuilds severely damaged cartilage. Results are best when cartilage damage is moderate, not advanced.