Reference entry

GHRP-2 (Pralmorelin)

Growth Hormone Releasing Peptide-2 · Pralmorelin

Research use onlyGBP reference pricing where listedUK dispatch on catalogue items

Overview

GHRP-2 is a synthetic growth hormone secretagogue that stimulates the pituitary gland to release growth hormone. It is one of the most potent members of the GHRP family, being 2-3 times more effective than GHRP-6 in stimulating GH release. Originally developed as a diagnostic agent for growth hormone deficiency, it…

GHRP-2 acts as a synthetic agonist of ghrelin, binding to the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary. This stimulates cAMP production and promotes pulsatile release of endogenous growth hormone without suppressing natural feedback loops. It works synergistically with GHRH to…

Used as a diagnostic agent in Japan for assessing growth hormone deficiency in clinical settings.

Stimulates endogenous growth hormone release through ghrelin receptor activation.

Indirectly increases IGF-1 levels through GH secretion.

Mechanism

Used as a diagnostic agent in Japan for assessing growth hormone deficiency in clinical settings.

Research areas

GHRP-2 is a synthetic growth hormone secretagogue that stimulates the pituitary gland to release growth hormone. It is one of the most potent members of the GHRP family, being 2-3 times more effective than GHRP-6 in stimulating GH release. Originally developed as a diagnostic agent for growth hormone deficiency, it…
GHRP-2 acts as a synthetic agonist of ghrelin, binding to the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary. This stimulates cAMP production and promotes pulsatile release of endogenous growth hormone without suppressing natural feedback loops. It works synergistically with GHRH to…
Used as a diagnostic agent in Japan for assessing growth hormone deficiency in clinical settings.
Stimulates endogenous growth hormone release through ghrelin receptor activation.
Indirectly increases IGF-1 levels through GH secretion.

Research notes

Increased appetite (less than GHRP-6)
Tingling or numbness in extremities
Tiredness or lethargy after injection
Severe or persistent headaches
Unusual swelling in hands or feet

Questions

Is GHRP-2 stronger than GHRP-6 for stimulating growth hormone?

Yes, GHRP-2 is 2-3 times more potent than GHRP-6 at stimulating GH release. However, GHRP-2 causes less appetite stimulation than GHRP-6, making it more tolerable for those sensitive to hunger effects. The trade-off is strength versus side effects—GHRP-2 is more with fewer appetite issues.

How much should I dose GHRP-2 with an empty stomach requirement?

Standard GHRP-2 dosing is 100-300mcg, 2-3 times daily on a completely empty stomach (2+ hours after eating). Wait 30 minutes after injection before consuming food to optimize GH release. Best timing is morning upon waking, post-workout, and bedtime when natural GH is already elevated.

Will GHRP-2 cause elevated cortisol like some sources suggest?

At recommended doses (100-300mcg), GHRP-2 rarely elevates cortisol significantly. However, very high doses (>300mcg) or frequent dosing can increase cortisol. Most side effects are manageable water retention and appetite, with cortisol elevation primarily a concern with dose escalation beyond therapeutic ranges.

Can I use GHRP-2 if I'm diabetic or glucose-sensitive?

GHRP-2 can modestly affect glucose metabolism through GH's insulin-antagonistic effects. Diabetic users require careful monitoring and possible insulin adjustment. For glucose-sensitive individuals, monitor blood sugar before, during, and after use. Medical supervision is recommended, particularly with…