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Peptide Database

Growth hormone & endocrine research

Hexarelin (Examorelin): Research Overview

Potent growth hormone-releasing peptide studied alongside GHRH in endocrine research.

Also known as examorelin · EP-23905 · Examorelin

Research use onlyStrongest evidence: animal studyReviewed
DatabaseReferences

What is Hexarelin?

Hexarelin is one of the most potent synthetic growth hormone secretagogues available. It stimulates GH release by binding to the GHS-R1a receptor in the pituitary and hypothalamus, mimicking the action of ghrelin. Notably, Hexarelin demonstrates synergistic effects when combined with GHRH, producing GH responses greater than the arithmetic sum of either peptide alone.

What is Hexarelin researched for?

  • Most potent GHRP for stimulating endogenous growth hormone release from the pituitary.
  • Produces synergistic GH release when combined with GHRH, greater than sum of individual effects.
  • Significant increases in IGF-1 levels through enhanced GH secretion.
  • Protective effects on cardiac tissue mediated through CD36 receptor activation.
  • Reduces apoptosis of cardiomyocytes and controls cardiac action potential.
  • Cardiotropic effects mediated by elevation of Ca2+ influx through voltage-gated calcium channels.
  • Beneficial effects on lipid metabolism via CD36 receptor in non-obese insulin-resistant models.
  • Improved lean mass to fat ratio through GH and IGF-1 elevation.

How does Hexarelin work?

Hexarelin binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain and pituitary gland. This binding initiates a signaling cascade that stimulates somatotroph cells in the anterior pituitary to produce and release growth hormone. Hexarelin also has slight, dose-dependent effects on prolactin, ACTH, and cortisol release.

Reported targets: GHS-R1a, growth hormone secretagogue receptor

References

  1. Hexarelin Improves Lipid Metabolic Aberrations in Insulin-Resistant Mice Endocrinology

    2017

    Hexarelin treatment improved lipid metabolism via CD36 receptor in non-obese insulin-resistant MKR mice.

    Animal study

  2. Effect of Repeated Hexarelin Administration on

    GH Responsivity European Journal of Endocrinology · 1996

    Demonstrated synergistic GH response when hexarelin co-administered with GHRH, greater than arithmetic sum.

  3. Hexarelin Modulates GHS-R1a Expression Neuroendocrinology

    2004

    Hexarelin significantly increased pituitary and hypothalamic GHS-R1a mRNA levels.

  4. Kinetics and Disposition of Hexarelin in

    Rats Drug Metabolism and Disposition · 1999

    Half-life of 75.9 min; rapidly absorbed subcutaneously; stable against proteolytic enzymes.

Common questions

Does hexarelin cause the same appetite stimulation as GHRP-6?

No. Hexarelin is significantly more potent for GH release while causing less appetite stimulation than GHRP-6. This makes it preferable if you want strong GH effects without the intense hunger that GHRP-6 typically triggers.