Ipamorelin

Growth Hormone Secretagogue · Selective GHRP

Overview

Selective GHRP that stimulates natural GH production from the pituitary with minimal cortisol and prolactin disruption. Known for its excellent safety profile and ability to produce consistent GH pulses without significant side effects common to other growth hormone releasing peptides.

Binds selectively to ghrelin receptors in pituitary gland, stimulating natural GH release with direct systemic delivery via injection, consistent GH pulse stimulation, no significant cortisol or prolactin elevation, and minimal hunger response.

Consistent GH elevation 30-60 minutes post-injection, maintaining natural pulsatile patterns.

Increases insulin-like growth factor-1 through natural GH pathways.

Supports cellular regeneration, collagen synthesis, and tissue repair.

Promotes muscle growth and maintenance through GH-mediated pathways.

Mechanism

Consistent GH elevation 30-60 minutes post-injection, maintaining natural pulsatile patterns.

Research areas

Selective GHRP that stimulates natural GH production from the pituitary with minimal cortisol and prolactin disruption. Known for its excellent safety profile and ability to produce consistent GH pulses without significant side effects common to other growth hormone releasing peptides.
Binds selectively to ghrelin receptors in pituitary gland, stimulating natural GH release with direct systemic delivery via injection, consistent GH pulse stimulation, no significant cortisol or prolactin elevation, and minimal hunger response.
Consistent GH elevation 30-60 minutes post-injection, maintaining natural pulsatile patterns.
Increases insulin-like growth factor-1 through natural GH pathways.
Supports cellular regeneration, collagen synthesis, and tissue repair.
Promotes muscle growth and maintenance through GH-mediated pathways.
Enhances lipolysis and metabolic rate through natural GH elevation.
Improved sleep latency and increased slow-wave sleep duration.
Enhanced recovery markers and reduced soreness after training.

Research notes

Mild hunger increase 20-30 minutes post-injection
Slight drowsiness when taken before bed
Water retention (mild)
Signs of receptor desensitization (reduced response after 3-4 months)
Unusual joint pain or swelling
Persistent numbness or tingling
Pregnancy or breastfeeding
Active cancer or history of cancer
Severe kidney or liver disease

AXIOM catalogue

Ipamorelin — research-use catalogue record with strengths and available batch details where listed.

References

FAQs

Why do users prefer ipamorelin over other GHRPs?

Ipamorelin is the most selective GHRP—it stimulates GH release without the appetite stimulation of GHRP-6, the prolactin elevation of GHRP-2, or the cortisol/ACTH effects of hexarelin. This selectivity makes it ideal for those wanting clean GH elevation with minimal side effects.

Is ipamorelin good for bedtime dosing?

Yes, excellent. A 200mcg dose 30 minutes before bed improves sleep quality and supports the natural nocturnal GH pulse. Many users report deeper, more restorative sleep with minimal side effects compared to morning dosing.

Can I stack ipamorelin with CJC-1295?

Yes, this is a popular and synergistic combination. CJC-1295 provides baseline GH elevation while ipamorelin adds pulsatile spikes. Together they extend GH release duration and amplitude beyond either peptide alone.

How long before ipamorelin stops working?

Ipamorelin typically maintains efficacy for 3-4 months before receptor desensitization develops. Many users take 4-week breaks every 12 weeks to reset receptor sensitivity and maintain responsiveness over time.