Research today. Impact tomorrow.

25% Off the entire catalogue →

Same standards. Greater possibilities.

Research Use Only18+Not for Human ConsumptionReconstitution Materials Not Supplied
Peptide Database

Reproductive & sexual-function research

Gonadorelin (GnRH): Research Overview

Synthetic gonadotropin-releasing hormone, approved as a diagnostic agent for reproductive function.

Also known as GnRH · LHRH · Factrel

Research use onlyStrongest evidence: early human studyReviewed
DatabaseReferences

What is Gonadorelin?

Gonadorelin is a synthetic form of the naturally occurring gonadotropin-releasing hormone (GnRH). It stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn regulate testosterone production in men and ovulation in women. It is FDA-approved for diagnostic testing and fertility treatment.

What is Gonadorelin researched for?

  • Treatment of conditions like Kallmann syndrome where GnRH deficiency causes low testosterone and infertility.
  • Induces ovulation in women with hypothalamic amenorrhea who don't ovulate regularly.
  • Stimulates testosterone and sperm production by restoring LH/FSH pulsatility.
  • Treatment of delayed puberty due to hypothalamic-pituitary dysfunction.
  • Used to assess hypothalamic-pituitary function and diagnose GnRH deficiency.
  • Evaluates pituitary reserve and responsiveness to GnRH stimulation.
  • Maintains testicular function and fertility during testosterone replacement therapy.
  • Helps restore natural testosterone production after anabolic steroid use.
  • Treatment of undescended testes in pediatric patients.

How does Gonadorelin work?

Gonadorelin acts as an agonist of the GnRH receptor in the anterior pituitary. When administered in pulses (mimicking natural secretion patterns every 60-120 minutes), it stimulates release of FSH and LH. LH then stimulates Leydig cells in the testes to produce testosterone, or triggers ovulation in women.

Reported targets: GnRH receptor

References

  1. Gonadorelin in Hypogonadotropic Hypogonadism Journal of Clinical Endocrinology & Metabolism

    2018

    Pulsatile GnRH administration effectively restores fertility in patients with hypothalamic hypogonadism.

    Early human study

  2. GnRH Pulsatility and Reproductive Function Frontiers in Endocrinology

    2020

    Pulsatile GnRH secretion (every 60-120 min) is essential for proper FSH/LH release and reproductive function.

  3. Gonadorelin for Ovulation Induction Fertility and Sterility

    2015

    Effective treatment for ovulation induction in women with hypothalamic amenorrhea.

Common questions

Is Gonadorelin better than hCG for maintaining testicular function during TRT?

Both Gonadorelin and hCG maintain testicular function and fertility during TRT, but they work differently. hCG directly mimics LH with a 24-36 hour half-life, while Gonadorelin stimulates natural LH/FSH release but requires pulsatile dosing. hCG is simpler to administer; Gonadorelin offers more physiological restoration of the HPG axis.